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Vitamin D sufficiency may reduce complications of COVID-19

A recent small-scale study has concluded that hospitalized patients with COVID-19 are less likely to have life threatening complications if they have sufficient vitamin D levels.A new study demonstrates that people with sufficient levels of vitamin D are less likely to develop life threatening COVID-19 complications when hospitalized with the disease.The research, published in the…

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Vitamin D sufficiency may reduce complications of COVID-19

A recent small-scale study has concluded that hospitalized patients with COVID-19 are less likely to have life threatening complications if they have sufficient vitamin D levels.A new study demonstrates that people with sufficient levels of vitamin D are less likely to develop life threatening COVID-19 complications when hospitalized with the disease.The research, published in the journal PLOS ONE, could be valuable for doctors attempting to reduce the mortality rates of COVID-19 in the absence of an effective vaccine.If further studies back up these findings, vitamin D supplements might offer a cost-effective way to limit the risk of severe COVID-19. It is important to note that this recent study has several limitations, which we address below.Stay informed with live updates on the current COVID-19 outbreak and visit our coronavirus hub for more advice on prevention and treatment.Since the sudden emergence of the virus SARS-CoV-2 and the disease that it causes, COVID-19, scientists have paid a great deal of attention to the development of a vaccine. Experts consider a vaccine to be crucial in reducing the effects of the virus, even if it is not yet clear to what extent an initial vaccine would moderate rates of transmission and infection.Alongside the endeavor to develop a vaccine, researchers are also focusing on developing effective COVID-19 treatments. Even if none can make a person immune to the virus, treatments may be able to reduce the disease’s severity.The Food and Drug Administration (FDA) have approved two drugs as treatments for COVID-19: remdesivir and dexamethasone.Another candidate is vitamin D. Research has suggested that it might, in theory, be effective, but corroborating this requires further efforts.Rather than analyzing the effects of vitamin D as COVID-19 treatment, the researchers behind the present study looked at the effects of a person’s vitamin D levels on the severity of the disease.To do so, they analyzed data from patients with confirmed COVID-19 who had been admitted to the Sina Hospital, in Tehran, Iran.Of the 611 people admitted with confirmed COVID-19 before May 1, 2020, there were records of the 25-hydroxyvitamin D levels, an indication of overall vitamin D levels, for 235 patients. Their mean age was 58.7 years, ranging from 20–90 years, and 37.4% were older than 65.The researchers classified the patients into two groups: those with vitamin D levels of at least 30 nanograms per milliliter (ng/ml) — an amount considered sufficient by the Endocrine Society — and those with lower values.They then analyzed the severity of the patients’ COVID-19 signs and symptoms using guidelines from the Centers for Disease Control and Prevention (CDC). Severe or critical disease might involve a range of issues, including shortness of breath, respiratory failure, or a significantly reduced blood oxygen level.After cross-checking the patients’ vitamin D levels with the severity of their COVID-19 symptoms and accounting for confounding factors, the researchers found that having a vitamin D level of above 30 ng/ml was significantly associated with having less severe COVID-19.Among the 235 patients with confirmed COVID-19, only 32.8% had sufficient levels of the vitamin.The researchers also found that the patients with sufficient vitamin D had higher blood lymphocyte counts and lower levels of C-reactive protein in their blood — both of which indicate a positive immune response.The researchers speculate that this may have reduced the likelihood of developing cytokine storm, which can cause acute respiratory distress syndrome in COVID-19 patients, sometimes resulting in death.The findings highlight, the researchers say, that vitamin D sufficiency may be important in the eventuality that people develop COVID-19 alongside another respiratory disease, such as influenza.According to the study’s corresponding author, Dr. Michael F. Holick, director of the General Clinical Research Unit at the medical campus of Boston University, in Massachusetts, “There is great concern that the combination of an influenza infection and a coronal viral infection could substantially increase hospitalizations and death due to complications from these viral infections.”For the researchers, their findings suggest that vitamin D supplementation would be valuable. As Dr. Holick notes: “Because vitamin D deficiency and insufficiency is so widespread in children and adults in the United States and worldwide, especially in the winter months, it is prudent for everyone to take a vitamin D supplement to reduce [the] risk of being infected and having complications from COVID-19.”It is worthing noting the present study’s limitations. First, the researchers only had access to a relatively small number of patients. Before drawing solid conclusions, scientists need to carry out much larger studies.Also, various issues can influence both vitamin D status and COVID-19 severity, such as socioeconomic factors and smoking status. The scientists accounted for neither of these in their analysis.Also, because the study was cross-sectional, the researchers could not prove that vitamin D insufficiency caused an increase in disease severity. To address these limitations, the researchers call for “large-scale studies and randomized clinical trials.”For live updates on the latest developments regarding the novel coronavirus and COVID-19, click here.
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Science & Health

Indian lunar orbiter hit by heat rise

From Harmeet Shah Singh CNN NEW DELHI, India (CNN) — Scientists have switched off several on-board instruments to halt rising temperatures inside India’s first unmanned lunar spacecraft. The spacecraft carrying India’s first lunar probe, Chandrayaan-1, lifts off from Sriharikota. Mylswamy Annadurai, the project director for the lunar mission, told CNN that temperatures onboard Chandrayaan-1 had…

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NEW DELHI, India (CNN) — Scientists have switched off several on-board instruments to halt rising temperatures inside India’s first unmanned lunar spacecraft.

For India the $80 million mission puts the country on the inside track of a fast-developing Asian space race.

The spacecraft carrying India’s first lunar probe, Chandrayaan-1, lifts off from Sriharikota.

Mylswamy Annadurai, the project director for the lunar mission, told CNN that temperatures onboard Chandrayaan-1 had risen to 49 degrees Celsius (120 degrees Fahrenheit).

The increase occurred as the craft, the moon — which it is orbiting — and the sun lined up, a phenomenon which Annadurai said was not unexpected and which would likely last until the end of December.

“We have switched off the systems (aboard) that are not needed to be on,” Annadurai said, ruling out the possibility of damage and adding that the temperature was now down to 40 degrees Celsius (104 degrees Fahrenheit).

Heat on board the Chandrayaan-1 should not exceed 50 degrees Celsius (122 degrees Fahrenheit), Annadurai said — but insisted the orbiter is designed to withstand up to 60 degrees Celsius (140 degrees Fahrenheit).

The Chandrayaan-1 — Chandrayaan means “moon craft” in Sanskrit — was successfully launched from southern India on October 22. VideoWatch the launch of India’s first lunar mission »

Its two-year mission is to take high-resolution, three-dimensional images of the moon’s surface, especially the permanently shadowed polar regions. It also will search for evidence of water or ice and attempt to identify the chemical composition of certain lunar rocks, the group said.

Earlier this month the Moon Impact Probe detached from Chandrayaan-1 and successfully crash-landed on the moon’s surface.

Officials say that the TV-size probe, which is adorned with a painting of the Indian flag, hit the moon’s surface at a speed of 5,760 kilometers per hour (3,579 mph).

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It transmitted data to Chandrayaan-1 ahead of impact but was not intended to be retrieved after that.

Chandrayaan-1 is carrying payloads from the United States, the European Union and Bulgaria. India plans to share the data from the mission with other programs, including NASA.

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Shuttle lands at California air base

(CNN) — Space shuttle Endeavour landed safely Sunday afternoon at California’s Edwards Air Force Base after NASA waved off two opportunities for a Florida landing because of poor weather. Endeavour glides in for a landing Sunday at California’s Edwards Air Force Base. The shuttle, steered by commander Christopher Ferguson, landed at 1:25 p.m., ending a…

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(CNN) — Space shuttle Endeavour landed safely Sunday afternoon at California’s Edwards Air Force Base after NASA waved off two opportunities for a Florida landing because of poor weather.

NASA opted to land the shuttle in California on Sunday, because of bad weather at Kennedy Space Center.

Endeavour glides in for a landing Sunday at California’s Edwards Air Force Base.

The shuttle, steered by commander Christopher Ferguson, landed at 1:25 p.m., ending a mission that lasted more than two weeks.

Wind, rain and reports of thunderstorms within 30 miles of the shuttle landing facility at Florida’s Kennedy Space Center prompted NASA to cancel the landing attempts there. Those had been scheduled for 1:19 p.m. and 2:54 p.m. ET.

After determining Monday’s weather forecast at Kennedy Space Center was equally unpromising, flight controllers decided they would try to land the shuttle and its seven astronauts at Edwards AFB, about 100 miles from Los Angeles, California, where Sunday’s forecast was sunny.

Flight controllers prefer landings at Kennedy Space Center because of cost and schedule. NASA has estimated it costs about $1.7 million to bring a shuttle home to Kennedy Space Center from California. VideoWatch Endeavour’s Sunday landing in California »

It also takes at least a week to get the shuttle ready for the trip, but schedule is not a major factor for the Endeavour; it is not scheduled to fly again until May.

Endeavour‘s 15-day mission to the international space station began on November 14 and included four spacewalks.

During that time, the crew brought key pieces — including exercise equipment, more sleeping berths and a urine recycling system — for a project to double the capacity of the station from three in-house astronauts to six.

The recycling system was installed to turn urine and sweat from the astronauts into drinking water.

Other modules are scheduled to arrive on a February shuttle flight. The goal of expanding the station’s capacity to six astronauts is expected to be reached by the summer.

The crew also worked on a joint that helps generate power for the space station. Heidemarie Stefanyshyn-Piper and Steve Bowen spent hours cleaning and lubricating the Solar Alpha Rotary Joint, which is designed to allow the solar panels on the left side of the station to rotate and track the sun.

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The astronauts also removed and replaced several trundle bearing assemblies.

The mission went according to plan, despite a minor interruption on the first spacewalk when a grease gun in Stefanyshyn-Piper tool’s bag leaked, coating everything inside with a film of lubricant. While she was trying to clean it up, the bag — with $100,000 in tools — floated away.

CNN’s Kate Tobin and Miles O’Brien contributed to this report.

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Inspiration for ‘Contact’ still listening

(CNN) — From a remote valley in Northern California, Jill Tarter is listening to the universe. Jill Tarter at the Allen Telescope Array in California, which monitors radio signals for signs of alien life. Her ears are 42 large and sophisticated radio telescopes, spread across several acres, that scan the cosmos for signals of extraterrestrial…

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(CNN) — From a remote valley in Northern California, Jill Tarter is listening to the universe.

Jill Tarter at the Allen Telescope Array in California, which monitors radio signals for signs of alien life.

Her ears are 42 large and sophisticated radio telescopes, spread across several acres, that scan the cosmos for signals of extraterrestrial origin. If intelligent life forms do exist on other planets, and they try to contact us, Tarter will be among the first to know.

Are we citizens of Earth alone in the universe? It’s a question that has long fascinated astronomers, sci-fi authors, kids with backyard telescopes and Hollywood executives who churn out spectacles about alien encounters. Polls have found that most Americans believe that some form of life exists beyond our planet.

“It’s a fundamental question,” said Tarter, the real-life inspiration for Jodie Foster’s character in the 1997 movie “Contact.” “And it’s a question that the person on the street can understand. It’s not like a … super-collider or some search for neutrinos buried in the ice. It’s, ‘Are we alone? How might we find out? What does that tell us about ourselves and our place in the universe?’

“We’re trying to figure out how the universe began, how galaxies and large-scale structures formed, and where did the origins of life as we know it take place?” Tarter said.

“These are all valid questions to ask of the universe. And an equally valid question is whether the same thing that happened here [on Earth] has happened elsewhere.” VideoWatch a preview of CNN’s “In Search of Aliens” series »

Thanks to advancements in technology, scientists hope to get an answer sooner rather than later. Rovers have snapped photographs of the surface of Mars that show fossil-like shapes. NASA hopes to launch within a decade a Terrestrial Planet Finder, an orbiting observatory that would detect planets around nearby stars and determine whether they could support life.

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Watch Miles O’Brien’s five-part series on aliens and UFOs, every day this week on CNN’s “American Morning”

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Such developments are catnip to scientists like Geoffrey Marcy, a professor of astronomy at the University of California-Berkeley who has discovered more extrasolar planets than anyone else.

“It wasn’t more than 13 years ago that we hadn’t found any planets around the stars, and most people thought that we never would. So here we are not only having found planets, we are looking for habitable planets, signs of biology on those planets,” Marcy told CNN. “It’s an extraordinary explosion of a field of science that didn’t even exist just a few years ago.”

Then there’s Tarter, whose quest for signs of extraterrestrial life kept her on the fringes of mainstream science for decades. While pursuing her doctorate at UC-Berkeley, Tarter came across an engineering report that floated the idea of using radio telescopes to listen for broadcasts by alien beings.

It became her life’s work. In 1984 Tarter founded the Search for Extraterrestrial Intelligence Institute (SETI) in California. Using telescopes in Australia, West Virginia and Puerto Rico, she conducted a decade-long scouring of about 750 nearby star systems for extraterrestrial radio signals.

None was found, although Tarter had some false alarms. In 1998, she intercepted a mysterious signal that lasted for hours. Tarter got so excited she misread her own computer results: The signal was coming from a NASA observatory spacecraft orbiting the sun.

Today, Tarter listens to the heavens with the Allen Telescope Array, a collection of 20-foot-wide telescopes some 300 miles north of San Francisco. The dish-like scopes are a joint effort of SETI and UC-Berkeley’s Radio Astronomy Lab and have been funded largely by Microsoft co-founder Paul Allen, who donated more than $25 million to the project.

Unlike previously existing radio telescopes, which scan the sky for limited periods of time, the Allen Telescope Array probes the universe round the clock.

Each of the 42 scopes is aimed at a different area of the sky, collecting reams of data that are continually studied by computers for unusual patterns. Then the listeners must filter out noise from airplanes and satellites.

“We’re listening for something that we don’t think can be produced by Mother Nature,” Tarter said. “We’re using the radio frequency, other people are using optical telescopes … and in both cases we’re looking for an artificial nature to a signal.

“In the case of radio, we’re looking for a lot of power being squished into just one channel on the radio dial. In the optical, they’re looking for very bright flashes that last a nanosecond … or less, not slow pulsing kinds of things. To date we’ve never found a natural source that can do that.”

Signals that any extraterrestrials might be transmitting for their own use would be difficult to detect, Tarter said. Astronomers are more likely to discover a radio transmission broadcast intentionally at the Earth, she said.

Astronomers at SETI, however, are not sending a signal into space in an attempt to communicate with aliens.

University of California professor Marcy is skeptical about the existence of intelligent alien life and believes our galaxy’s vast distances would make communication between Earth and beings on other planets almost impossible.

“The nearest neighbor might be halfway across our galaxy, 50,000 light-years away. Communicating with them will take a hundred thousand years for a round-trip signal,” he said.

Still, Tarter remains undaunted. The Allen Telescope Array already does in 10 minutes what once took her scientists 10 days. When the project is completed, it will have 350 telescopes that, combined, can survey tens of thousands of star systems.

“We can look in more places and more frequencies faster than we ever could. And that will just get better with time. We’re doing something now we couldn’t do when we started, we couldn’t do five years ago,” she said.

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“Think of it as a cosmic haystack. There’s a needle in there somewhere. If you pull out a few straws, are you going to get disappointed because you haven’t found the needle yet? No. We haven’t really begun to explore.”

CNN correspondent Miles O’Brien contributed to this story.

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