Connect with us
[adrotate group="1"]

Middle East News

New nano drug candidate kills aggressive breast cancer cells

Metal-organic frameworks are an emerging class of nanomaterials designed for targeted drug delivery. Researchers have developed a new nano-drug candidate that kills triple negative breast cancer cells, which is one of the most aggressive and fatal types of breast cancer. The study, published in the journal Advanced Therapeutics, will help clinicians target breast cancer cells…

Published

on

New nano drug candidate kills aggressive breast cancer cells

Metal-organic frameworks are an emerging class of nanomaterials designed for targeted drug delivery.

Researchers have developed a new nano-drug candidate that kills triple negative breast cancer cells, which is one of the most aggressive and fatal types of breast cancer.
The study, published in the journal Advanced Therapeutics, will help clinicians target breast cancer cells directly while avoiding the adverse, toxic side effects of chemotherapy.
The research team linked a new class of nanomaterials, called metal-organic frameworks, with the ligands of an already-developed photodynamic therapy drug to create a nanoporous material that targets and kills tumour cells without creating toxicity for normal cells.
Metal-organic frameworks are an emerging class of nanomaterials designed for targeted drug delivery. Ligands are molecules that bind to other molecules, the study said.
“Patients with triple-negative cells are especially vulnerable, because of the toxic side effects of the only approved treatment for this type of cancer,” said study researcher Hassan Beyzavi from the University of Arkansas in the US.”We’ve addressed this problem by developing a co-formulation that targets cancer cells and has no effect on healthy cells,” Beyzavi added.
The researcher’s focus is on developing new, targeted photodynamic therapy drugs.
As an alternative to chemotherapy – and with significantly fewer side effects – targeted photodynamic therapy, or PDT, is a non-invasive approach that relies on a photosensitizer that, upon irradiation by light, generates so-called toxic reactive oxygen species, which kill cancer cells.
In recent years, PDT has garnered attention because of its ability to treat tumours without surgery, chemotherapy or radiation.
Beyzavi’s laboratory has specialised in integrating nanomaterials, such as metal-organic frameworks, with PDT and other and therapies. Metal-organic frameworks significantly enhance the effectiveness of PDT.
The research team prepared the nanomaterials and then bio-conjugated them with ligands of the PDT drug to create nanoporous materials that specifically targeted and killed tumour cells with no toxicity in normal cells.
“In addition to cancer treatment, this novel drug delivery system could also be used with magnetic resonance imaging (MRI) or fluorescence imaging, which can track the drug in the body and monitor the progress of cancer treatment,” the study authors wrote.

Continue Reading
Click to comment

Leave a Reply

Your email address will not be published. Required fields are marked *

*

code

Middle East News

Children killed in attack on Cameroonian school

Assailants storm private school in city of Kumba, Southwest Region, killing at least four students.Attackers have opened fire on a private school in Cameroon’s Southwest Region, killing at least four children, according to officials. The unknown assailants stormed the Mother Francisca School in the city of Kumba on Saturday. There was no immediate claim of…

Published

on

By

Children killed in attack on Cameroonian school

Assailants storm private school in city of Kumba, Southwest Region, killing at least four students.Attackers have opened fire on a private school in Cameroon’s Southwest Region, killing at least four children, according to officials.
The unknown assailants stormed the Mother Francisca School in the city of Kumba on Saturday. There was no immediate claim of responsibility.
“They attacked around noon. They found the children in a class and they opened fire on them,” Kumba sub-prefect Ali Anougou told the Reuters news agency.
At least nine other students were wounded and sent to the hospital. There were fears the death toll could rise.
The Associated Press news agency quoted Anougou as blaming separatists who have been fighting the military in parts of western Cameroon for the attack.

Cameroon’s two Anglophone regions – the Northwest and Southwest Regions – are home to a large minority of English speakers in a country where French speakers are the overwhelming majority – a situation that is the legacy of the decolonisation of western Africa by France and Britain more than 60 years ago.
In late 2016, long-standing complaints of political and economic discrimination against English speakers by the central government spilled over when lawyers, students and teachers began calling for reforms.
The government’s lethal response to the protests provoked rebels to declare in 2017 independence for a region they call “Ambazonia”, triggering a stronger crackdown by the authorities.
Both sides have since been accused of committing atrocities in a conflict that has killed some 3,000 people and forced hundreds of thousands of people from their homes.
Anglophone secessionists have imposed curfews and closed schools as part of their protest against President Paul Biya’s government.
Last year, officials blamed separatists for kidnapping dozens of schoolchildren, charges the separatists denied.

Continue Reading

Middle East News

Vietnamese envoy hails KRCS’ global humanitarian efforts

KRCS Chairman Dr Hilal Al-Sayer meets Vietnamese Ambassador to Kuwait Trinh Minh Manh. – KUNAKUWAIT: Vietnamese Ambassador to Kuwait Trinh Minh Manh hailed the humanitarian efforts of Kuwait Red Crescent Society (KRCS) around the world. The remarks were made to KUNA yesterday after the ambassador’s meeting with KRCS Chairman Dr Hilal Al-Sayer. He expressed appreciation…

Published

on

By

Vietnamese envoy hails KRCS’ global humanitarian efforts

KRCS Chairman Dr Hilal Al-Sayer meets Vietnamese Ambassador to Kuwait Trinh Minh Manh. – KUNAKUWAIT: Vietnamese Ambassador to Kuwait Trinh Minh Manh hailed the humanitarian efforts of Kuwait Red Crescent Society (KRCS) around the world. The remarks were made to KUNA yesterday after the ambassador’s meeting with KRCS Chairman Dr Hilal Al-Sayer. He expressed appreciation for the society’s aid to the Vietnamese Embassy during the coronavirus crisis.

The ambassador added that they discussed providing his country with aid to face the impact of the recent floods and landslides, considered to be the worst in decades. Sayer said he was pleased with the ambassador’s visit and affirmed that KRCS will continue exerting humanitarian efforts to aid those affected by natural disasters and crises everywhere. – KUNA

Continue Reading

Middle East News

Pain, frustration: Expats lose jobs to new rules and COVID

File photos show foreign workers applying to leave Kuwait during the amnesty. – Photos by Yasser Al-ZayyatBy Chidi Emmanuel After working for 24 years in Kuwait, Charley Lyon received the dreaded letter that many expats fear amid the economic downturn, coronavirus pandemic and new residency laws. Lyon is among thousands of expat workers in the…

Published

on

By

Pain, frustration: Expats lose jobs to new rules and COVID

File photos show foreign workers applying to leave Kuwait during the amnesty. – Photos by Yasser Al-ZayyatBy Chidi Emmanuel

After working for 24 years in Kuwait, Charley Lyon received the dreaded letter that many expats fear amid the economic downturn, coronavirus pandemic and new residency laws. Lyon is among thousands of expat workers in the government sector who were being laid off.

As part of its Kuwaitization policy, Kuwait is replacing expats with locals in the government sector. The government has also stopped issuing work permits to expats over 60 years of age without a university degree. These new rules have had a huge impact on the lives of thousands of expats in the country, leaving many with no choice but to pack their bags and leave.

Gulf countries are facing an exodus of foreign workers as the coronavirus pandemic pushes out foreign workers. In the midst of the COVID-19 and financial crunch, the National Assembly approved a draft law to slash expat numbers over the next five years.

As the budget deficit widens and economic conditions worsen, Kuwait is grappling with an economic downturn as COVID-19 continues to wreak havoc around the world. The combined shock of collapsing oil prices, the pandemic and joblessness is reshaping labor policies in the region, thus bringing anti-foreigner sentiments to the fore again.

While Kuwait’s expats struggle to secure their jobs, the government is calling for an increase in workforce nationalization in government entities. “Why will foreigners take the jobs meant for us (Kuwaitis)? They can work anywhere – but not in the ministries,” argued Abdullah, a 26-year-old Kuwaiti.

Buttressing Abdullah’s viewpoint, Fatma, an unemployed Kuwaiti woman, complained of the difficulty in competing with foreign workers for jobs in the private sector. “Foreign workers can work longer for less, unlike us Kuwaitis. So most companies prefer to hire non-Kuwaitis. This leaves us with only one sector (the public sector). I think this is why the government introduced Kuwaitization, so as to give unemployed Kuwaitis an opportunity,” she explained.

For Lyon, justice and fairness should override anti-expat sentiments. “It is understandable that ministries would give preference to locals for jobs during these tough times, but it would be fair to consider the efforts of the old staff who have put in their best to build this country,” Lyon, 61, and some of his co-workers who were laid off recently lamented, as they worry about their future.

Expats make up the majority of the population of Kuwait. Residency is tied to employment and Kuwait does not easily offer citizenship routes to non-nationals. “We have been here (in Kuwait) legally for over 20 years. It will be difficult to go back and start afresh in our home countries. More so, Kuwait’s residency is linked to the work permit – when you lose your job, you automatically lose your residency. I worry about my children who are still in school. The three-month notice will not be enough to relocate them,” Mustapha, an Egyptian expat who recently lost his job, said in dismay.

Abdurazak Hamad, an African expat, is in a dilemma. “I feel miserable leaving my family behind. I don’t want to go alone, but I can’t make my wife quit her KD 450 job since she is now the sole breadwinner. Starting afresh in my home country at this age (62) will be very difficult. I wish I can get a permit (residency) to stay here with my family,” said Hamad, who was recently sacked.

Continue Reading
error: Content is protected !!