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Gilead’s remdesivir shows modest improvement in moderate COVID-19 patients

(Reuters) – Gilead Sciences Inc on Monday reported that its antiviral drug remdesivir provided a modest benefit in patients with moderate COVID-19 given a five-day course of the treatment, while those who received the medicine for 10 days in the study did not fare as well. FILE PHOTO: An ampule of Ebola drug Remdesivir is…

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Gilead’s remdesivir shows modest improvement in moderate COVID-19 patients

(Reuters) – Gilead Sciences Inc on Monday reported that its antiviral drug remdesivir provided a modest benefit in patients with moderate COVID-19 given a five-day course of the treatment, while those who received the medicine for 10 days in the study did not fare as well. FILE PHOTO: An ampule of Ebola drug Remdesivir is pictured during a news conference at the University Hospital Eppendorf (UKE) in Hamburg, Germany, April 8, 2020, as the spread of coronavirus disease (COVID-19) continues. Ulrich Perrey/Pool via REUTERS/File PhotoGilead shares fell about 4%. Remdesivir, which is administered intravenously in hospital, is the first drug to show improvement in COVID-19 patients in formal clinical trials, and new information about its efficacy is being closely watched around the world, as nations battle the pandemic. The late stage study of nearly 600 patients evaluated the safety and efficacy of 5- and 10-day treatment with remdesivir in addition to standard care for those with moderate COVID-19 – the disease caused by the new coronavirus – compared with standard care alone. At day 11, around 76% of the patients in the 5-day treatment group showed improvement in clinical status versus 66% for standard care alone, Gilead said. Around 70% of the patients who received remdesivir for 10 days showed improvement, “trending toward but not reaching statistical significance,” the drugmaker said. Further study details than Gilead provided on Monday, such as more information on patient demographics, are needed to explain the difference in the two treatment groups, doctors and analysts said. Remdesivir is being closely watched after the U.S. Food and Drug Administration granted emergency use authorization (EUA)last month, citing results from a U.S. government study that showed the drug reduced hospitalization stays by 31%, or about four days, compared to a placebo. The FDA did not immediately respond to a request for comment on whether it would consider expanding the EUA, and Gilead told Reuters it was in discussions with the regulator to determine the appropriate patients to be treated under the authorization. There are currently no treatments with U.S. approval or vaccines for the new coronavirus that has infected more than 6 million people and killed nearly 373,000 worldwide, including over 104,000 U.S. deaths. The drug has received approval by Japanese health regulators. U.S. approval requires a rigorous, time consuming FDA review, but EUAs can be used in a health crisis when other options are not available. Dozens of companies are working on a variety of treatment and vaccine approaches for the illness. The drug, which previously failed as a treatment for Ebola, is designed to disable the mechanism by which certain viruses, including the new coronavirus, make copies of themselves and potentially overwhelm their host’s immune system. Dr. Daniel McQuillen, an infectious disease specialist at Lahey Hospital & Medical Center in Burlington, Massachusetts, said it was difficult to draw a conclusion on why the patients on the shorter course outperformed those on the longer one until the full data is released. The trial results “confirm our and others’ anecdotal experience,” McQuillen said in an email. “The drug has promise in hospitalized patients treated early, when the illness is still in its viremic phase,” meaning the virus is circulating in a patient’s bloodstream. Jefferies analyst Michael Yee said the improvements seen were only modest. “This incrementally adds to a broader utilization of the drug into a more moderate population inside the hospital, but consensus already understands remdesivir is not a silver bullet,” Yee wrote in a research note. Reporting By Ankur Banerjee, Deena Beasley and Michael Erman; Editing by Alistair Bell and Bill Berkrot
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Most of the US is headed in the wrong direction again with Covid-19 cases as deaths near 200,000

(CNN)Despite making progress after a difficult summer, most of the US is heading in the wrong direction again as the nation closes in on 200,000 Covid-19 deaths.In 31 states, the number of new Covid-19 cases has increased by at least 10% this past week compared to the previous week, according to data Sunday from Johns…

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Most of the US is headed in the wrong direction again with Covid-19 cases as deaths near 200,000

(CNN)Despite making progress after a difficult summer, most of the US is heading in the wrong direction again as the nation closes in on 200,000 Covid-19 deaths.In 31 states, the number of new Covid-19 cases has increased by at least 10% this past week compared to the previous week, according to data Sunday from Johns Hopkins University. Only four states — Delaware, Hawaii, Louisiana and Michigan — have had decreases of more than 10%. Fifteen states are holding steady, including Alaska, Arkansas, California, Georgia, Illinois, Maine, Maryland, Nevada, North Carolina, Ohio, Oregon, Pennsylvania, Rhode Island, Virginia and Washington state.And the test positivity rate — the percentage of new test results that are positive — is rising in 25 states, according to the Covid Tracking Project.This is exactly what doctors feared would happen in the weeks following Labor Day, said Dr. Ashish Jha, dean of the Brown University School of Public Health. “A couple of weeks ago, as we went in to Labor Day, we were talking about exactly this — and our worry that coming out of Labor Day, as we’ve seen after Memorial Day and July Fourth, we’d see an increase,” he said.”And unfortunately, we’re walking into the fall, where weather gets colder. We’re going to spend more time indoors. So this is not where we want to be as a country right now.” Utah set a new record high of 1,117 cases on Friday, Gov. Gary Herbert said Saturday. Herbert extended Utah’s state of emergency until October 20. Wisconsin also reported a record number of new cases — 2,533 on Friday. Health officials urged people to stay home, keep at least 6 feet of distance from those outside their household, and wear masks in public. Nationwide, more than 6.7 million people have been infected with coronavirus, according to Johns Hopkins University data. As of 3:45 p.m. ET Sunday, more than 199,400 have died.A state doing well says keep up the testingBut some states are showing continued progress. On Sunday, Maryland announced a new record-low test positivity rate — 1.89%. And there’s more good news. “Total current hospitalizations have fallen below 300 for the first time since March 30, to 281,” Gov. Larry Hogan’s office said. “There are 68 ICU beds in use — the first time ICU levels have dropped below 70 since March 26.”Many health experts say widespread testing is key to finding asymptomatic or pre-symptomatic carriers, so those people can isolate and prevent the virus’ spread. In Maryland, state officials “continue to encourage all Marylanders to get tested for COVID-19” at one of the state’s 210 testing sites. Study find more links between pandemic and mental healthAs Covid-19 intensified in the US, so did levels of stress and depression, according to a study published in the journal Science Advances. The study of more than 6,500 people found that several factors may have worsened people’s stress.The biggest risk for symptoms of depression was a pre-existing mental health diagnosis prior the pandemic, researchers found.But symptoms of stress and depression were also associated more with personal exposure, rather than public spread — suggesting “concerns about contracting the disease outweighed concerns about pandemic-related disruptions in daily life,” the researchers said.”Approximately a quarter of the sample (23.5%) reported that they or a close other had been exposed to COVID-19 (e.g., experienced symptoms, were diagnosed),” researchers wrote in the report published Friday.Employment also had a big impact, with those who lost their jobs suffering most, the study found. The “data suggest that individuals who continued working during this early phase of the pandemic were less depressed than individuals who were not working, even though they were at greater risk for contracting the virus,” the researchers said.Those “remaining employed as an ‘essential’ worker may have given new meaning to respondents’ work that reduced their risk for depression.”Researchers said another factor in pandemic-related stress is how often participants were exposed to conflicting information from the news and social media. People were immersed in news an average of seven hours a day, they found, and acute stress increased as time went on.But consistent, accurate and reliable news reports may be one of the best ways to control stress, the researchers suggested.Why Black and Hispanic Americans often suffer moreNot everyone has the luxury of working from home. And since many minorities have public-facing jobs, this pandemic has hit them especially hard. “American Indians and Alaskan Natives and African Americans have been hospitalized at rates 3.5 times higher than Whites,” US Surgeon General Dr. Jerome Adams said. “Hospitalization rates are three times higher for Hispanics compared to Whites.”The pandemic exposes health disparities and structural conditions that contribute to those disparities, the surgeon general said. “Social distancing and teleworking are critical to preventing spread of coronavirus, yet only one in five African Americans and one in six Hispanic Americans have a job that allows him to work from home,” Adams said. People of color are also more likely to live in “densely packed urban areas” and in multi-generational homes. They’re also more likely to use public transportation, he said.”Combined, these and other factors create a greater risk for spread of a highly contagious disease like Covid-19.”CNN’s Gregory Lemos and Lauren Mascarenhas contributed to this report.
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‘Stunning’: Dr. Gupta reacts to Washington Post White House report – CNN Video

Chat with us in Facebook Messenger. Find out what’s happening in the world as it unfolds.JUST WATCHED’Stunning’: Dr. Gupta on Washington Post White House reportReplayMore Videos …MUST WATCHCNN’s Dr. Sanjay Gupta reacts to a report from the Washington Post that claims the White House stopped a plan by the United States Postal service to mail…

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‘Stunning’: Dr. Gupta reacts to Washington Post White House report – CNN Video

Chat with us in Facebook Messenger. Find out what’s happening in the world as it unfolds.JUST WATCHED’Stunning’: Dr. Gupta on Washington Post White House reportReplayMore Videos …MUST WATCHCNN’s Dr. Sanjay Gupta reacts to a report from the Washington Post that claims the White House stopped a plan by the United States Postal service to mail 650 million masks to Americans.Source: CNNStories worth watching (15 Videos)’Stunning’: Dr. Gupta on Washington Post White House reportRide along in the latest Ferrari convertibleWhy Trump’s war on WeChat could hurt American businessesAnother 860,000 Americans filed first-time jobless claimsBrianna Keilar calls out Fox News guest’s Covid-19 misinformationFed signals low rates through 20233M CEO: Meeting demand for N95 masks is still a challengeThe stock market boom doesn’t help everyoneSnowflake’s market debut is biggest software IPO everNissan gives a glimpse of its first Z car in more than a decadeMillions of Americans are out of work. Why is the stock market soaring?See robot stacking shelves in JapanAmazon is booming while small businesses struggleLG’s new smartphone has a unique swivel screenThis was Apple’s first ‘iPad.’ It failed miserablyHere’s one thing Joe Biden and President Trump actually agree onSee MoreNew DayCNN’s Dr. Sanjay Gupta reacts to a report from the Washington Post that claims the White House stopped a plan by the United States Postal service to mail 650 million masks to Americans.Source: CNN
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A rare blue moon will light up the sky on Halloween

The night sky on Halloween will be illuminated by a blue moon, the second full moon in a month. The relatively rare occurrence happens once every two and a half years on average, according to NASA’s National Space Science Data Center.Every month has a full moon, but because the lunar cycle and the calendar year…

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A rare blue moon will light up the sky on Halloween
The night sky on Halloween will be illuminated by a blue moon, the second full moon in a month. The relatively rare occurrence happens once every two and a half years on average, according to NASA’s National Space Science Data Center.

Every month has a full moon, but because the lunar cycle and the calendar year aren’t perfectly synched, about every three years we wind up with two in the same calendar month.

The National Weather Service spotted a massive bat colony on its weather radar
October’s first full moon, also known as the harvest moon, will appear on the first day of the month. The second full moon, or blue moon, will be visible on October 31. It’s the first instance of a blue moon in the Americas since March 2018.
It’s also the first time a Halloween full moon has appeared for all time zones since 1944, according to Farmers’ Almanac. The last time a Halloween full moon appeared was for the Central and Pacific time zones in 2001.

The “once in a blue moon” phenomenon does not necessarily mean the moon will look blue on Halloween. While the dark blue tone of an evening sky can affect the coloring we see, Earth’s satellite will most likely not appear blue at all.

Typically, when a moon does take on a bluish hue, it is because of smoke or dust particles in the atmosphere, such as during a major volcanic eruption.

When the phrase “once in a blue moon” was coined, it meant something so rare you’d be lucky (or unlucky) to see in your lifetime, according to NASA.

So if anything unusual happens to you on Halloween, there might just be a good reason why.

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